![]() At one extreme, the eye is hardly recognisable and non-functional-having been compressed by an orbital cyst, while at the other, one finds minimalistic involvement that hardly affects the structure and function of the eye. Ocular colobomata are more often associated with systemic abnormalities when caused by chromosomal abnormalities. ![]() The occurrence of coloboma can be sporadic, hereditary (known or unknown gene defects) or associated with chromosomal abnormalities. ![]() ![]() Typical ocular coloboma is caused by defective closure of the embryonal fissure. ![]()
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